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A New Treatment Doubles Mesothelioma Survival Rates

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A study at the University Hospital of Udine, Italy found that radical hemithoracic radiology, a new treatment doubles mesothelioma survival rates. The patients studied had cancers that were unable to be totally removed with surgical procedures. Mesothelioma patients generally live a year or, more rarely, up to two years. In this study of 108 patients, half were randomly selected to receive the new treatment and half the more palliative radiotherapy. Of those receiving the new, 58% were still living at two years. Of patients who received the more palliative radiotherapy, only 28% were still living at two years.

Mesothelioma and asbestos

The relationship between asbestos and mesothelioma is well known. The fibers from asbestos – smaller than a human hair – can embed in the layers of tissue surrounding the lungs. Not everyone exposed to asbestos contracts the disease, but it’s always a possibility. It’s an aggressive and fatal cancer that can take up to 50 years for a diagnosis. Current treatments are limited, so all new strides deserve a celebration.

Radical hemithoracic radiology a hopeful improvement for survival

Marco Trovo, MD, leader of the study and Chief of the Radiation Oncology Department at the University Hospital said, “There is an urgent need for more effective treatments for mesothelioma. Surgery can be given to these patients, but it is often impossible to remove all of the tumor. Patients with mesothelioma are sometimes given radiotherapy to help control their symptoms. However, radiotherapy has evolved dramatically in the last few years, so we wanted to see if it could now be used to prevent the cancer from spreading to nearby tissue, hopefully bringing improvements in survival.”

About 20% of the new radical treatment patients did develop radiation pneumonitis as a side effect. Professor Umberto Ricardi, President of ESTRO and head of the Department of Oncology at the University of Turin, Italy stated, “This is an extremely positive result that brings good news to patients with this rare and difficult-to-treat cancer. To ensure these patients benefit from this type of treatment, it’s important that they are referred to a specialist cancer centre with the right expertise and equipment to carefully plan and deliver the most effective radiotherapy treatment and manage any side effects that occur.”

New treatment doubles mesothelioma survival

Dr. Trovo said, “This research shows a clear survival benefit in using this type of radiotherapy for [patients with] mesothelioma whose tumors can only partially be removed by surgery. We believe that this should be considered the new standard of care for these patients.”

He believes that even longer survival rates could be made by using the new radiation technique followed by an immunotherapy technique that uses the patient’s immune system to target and fight the cancer cells. Creative scientific studies continue throughout the world with the goal of curing the deadly disease.

First New Mesothelioma Therapy Approved by FDA in Over 15 Years

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The first new mesothelioma therapy approved by the FDA is based on a trial. In this single-arm STELLAR trial, the median overall survival rate was 18.2 months with patients with unresectable, locally advanced or metastatic malignant pleural mesothelioma who received TTF plus chemotherapy. This combination of treatments comprises the NovoTTF-100L System along with pemetrexed and platinum-based chemotherapy for front-line treatment.

History of new mesothelioma therapy

Bill Doyle, executive chairman of Novocure, the developer of NovoTTF-100L stated, “Since 2000, we have been developing and commercializing Tumor Treating Fields (TTF) to extend survivals in some of the most aggressive forms of cancer. FDA approval of NovoTTF-100L provides patients with the first FDA-approved treatment for MPM in more than 15 years and, as our first FDA-approved torso cancer indication, marks a major milestone for Novocure. We are thankful for the patients, caregivers and health care providers who partnered with us to make this possible.”

What is malignant pleural mesothelioma (MPM)?

Strongly linked to asbestos exposure, MPM is a rare malignancy. Approximately 3,000 people are diagnosed with MPM each year in the US. This new therapy is welcome news as there was only one FDA-approved therapy prior to the NovoTTF-100L approval. That treatment consisted of pemetrexed plus cisplatin.

In addition to extending life, this new mesothelioma therapy approved by the FDA, is noninvasive, delivering TTF directly to the region of the tumor. No increase in serious systemic wide effects were noted with this new therapy.

Results showed patient overall survival at:
• 21.2 months for epithelioid malignant pleural mesothelioma (53 patients)
• 12.1 month for non-epithelioid malignant pleural mesothelioma (21 patients)
• 62% of those in the STELLAR study were alive at one year.
• Disease control when at least one CT scan was given as a follow-up was 97% (72 patients).

Mary Hesdorffer, NP, executive director of the Mesothelioma Applied Research Foundation, said “MPM is a devastating disease, with only 10 to 20 percent of patients being candidates for surgery to remove the tumor. Typically, mesothelioma patients who cannot have surgery receive palliative care to mitigate their symptoms. NovoTTF-100L provides unresectable MPM patients with a treatment option that may improve survival. We are encouraged by the FDA approval and hope it is just the beginning of innovation in the treatment of this aggressive disease.”

Should a Mesothelioma Patient Receive the Flu Vaccine

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Since there are conflicting opinions on getting the flu vaccine, should a mesothelioma patient receive the flu vaccine? These patients in particular, along with the elderly, young children, and people living with some chronic health issues, should assess the pros and cons of receiving the vaccine.

What do the experts say?

According to the Centers for Disease Control and Prevention (CDC), flu vaccines given with a needle cannot cause the flu. Even the vaccine given through a nasal spray, though it has a live virus, has been weakened and cold-adapted so it cannot infect a person as it would not survive the body’s warmth. Because there are a number of vaccines available, anyone with health problems should confer with their doctor to receive the correct one.

The CDC strongly encourages everyone to get the vaccine since flu is a serious, and sometimes deadly, disease. The risk of not getting the vaccine is greater than receiving it.

Currently, that means a shot or nasal spray every year as the virus is seasonal. Fortunately, there is a new type of vaccine on the horizon that may mean a vaccine only every few years.

The Universal Flu Vaccine

For decades, scientists searched for a universal vaccine that could eliminate the yearly shot and cover a variety of flu viruses. This is important, not only for patient convenience, but seasonal vaccine development means scientists have to guess what virus may be prevalent in any one year. A universal vaccine could eliminate that problem.

Currently, there are numerous vaccines in various stages of development. The one currently closest to release is the M-001 by BiondVax Pharmaceuticals Ltd. The company has recently enrolled its final participant so it can begin a Phase 3 trial.

Tamar Ben-Yedidia, the chief scientific officer at BiondVax, stated, “A universal flu vaccine is often referred to as “’The Holy Grail’ of influenza research, and like the Holy Grail, it is challenging to achieve.” He also said in a press release, “This challenging trial aims to show the extent to which M-001 protects people against influenza illness, regardless of the flu strain.” The M-001 vaccine is free of all viruses, but instead contains nine viral epitopes – the antibody binding sites on an antigen – which are recognized by the immune system.

Though the M-001 is currently furthest along in trials, all the flu vaccines use similar strategies. They target the least variable parts of the flu virus to produce immunity.

Why Should a Mesothelioma Patient Receive the Flu Vaccine?

As expressed by the CDC, a person with already weakened systems, such as the lungs, is more at risk of harm by getting the flu rather than getting a vaccine. Not only should the mesothelioma victim be vaccinated, but all those people normally around them.

Since a universal vaccine will mean a more successful and targeted answer to various flu viruses, chances of actually contracting the flu will be less. Those with mesothelioma already fight a serious disease and anything they can do to stay healthy will assist in that fight. This universal flu vaccine is one more tool to prolong life and ease the pain and discomfort of this detestable disease.

New Test for Cancer Diagnoses Shows Promise

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Currently, tests to determine if there are cancer cells in a person take at least a week before getting results, but a new test for cancer diagnoses shows promise with results seen in ten minutes.

What is this test?

This test is based on a discovery by researchers at the University of Queensland’s Australian Institute for Bioengineering and Nanotechnology (AIBN). What they discovered is a one-of-a-kind DNA signature that seems to be common to all types of cancer. They found this unique DNA in intense clusters of methyl groups in certain locations.

One of the researchers at AIBN, Professor Matt Trau, explained, “Virtually every piece of cancerous DNA we examined had this highly predictable pattern. It seems to be a general feature for all cancer. It’s a startling discovery.” This discovery was followed by another showing that when these methyl clusters are inserted into a solution, the cancer DNA pieces fold into 3-dimensional nanostructures and, at that point, can stick to gold.

Once researchers found this, they created a test using gold nanoparticles that change color if 3D nanostructures of cancer DNA are present. “This happens in one drop of fluid. You can detect it by eye, it’s as simple as that,” revealed Professor Trau. This is basically the same technology as using strip indicators to test for pregnancy.

Cancer diagnoses benefits found so far:

• Works on all types of cancers tested to date
• Simple – no complicated and expensive lab equipment needed
• Fast – results in 10 minutes
• Portable – eventually could test via mobile phone
• Accuracy – as high as 90% in some cancers

Is there a downside?

This test is new. It is not perfect. Will it give too many false positive diagnoses? Does it truly identify all types of cancer – or were researchers just fortunate in which ones were tested? Only time will tell, but the future appears to be very promising.

What is the future?

This technology was tested on 200 samples using cells from various types of cancers as well as healthy cells, but a great deal more testing is needed before this is generally accepted and available.

The simplicity and affordability of this test could mean life or death for many. Researchers tested their discovery on multiple types of breast cancer, colorectal cancer, prostate cancer, and lymphoma – all with good results. Hopefully it will soon be tested on asbestos lung cancer and mesothelioma as a quick diagnosis could accelerate treatment.

Dr. Abu Sina, an AIBN researcher, said, ”It works for tissue derived genomic DNA and blood derived circulating free DNA. This new discovery could be a game-changer in the field of point of care cancer diagnostics.” That is the hope for all and a research worth watching.

Studies Continue in Search of a Mesothelioma Cure

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Mesothelioma is a disease primarily caused by asbestos exposure and is usually fatal within a short period of time, however studies continue in search of a mesothelioma cure. This is not a simple task, as researchers are still not sure of the reason asbestos fibers encourage cancer in some individuals. With the long latency period between exposure and diagnosis, people will be fighting this disease for many decades to come. That means that new treatments to defeat the disease are urgently needed.

In the past, and currently, treatments often consisted of chemotherapy, radiation therapy, or surgery. These have extended the lives of many patients and they still do. However, as noted by the American Cancer Society, there are new studies and treatments that carry the promise that they may do more than extend life for a few months and actually bring about a cure.

What are the latest treatments?

While there are treatments currently in use, they are often limited in their effect and generally extend life a little longer rather than cure the disease. New ideas and studies take place all the time. Some of the newest treatments still under testing are listed below.

Immunotherapy

Clinical trials are underway using a patient’s own immune cells to attack their cancer. These cells are removed from the blood, taken to the lab where they are manipulated to react to tumor cells. They are then put back into the patient’s body through a blood transfusion. The presumption is these transformed immune cells will encourage the patient’s immune system to kill the cancer cells.

One other immunotherapy in trials uses tremelimumab, a drug that encourages the immune system to attack full force as it targets specific immune cells.

Gene therapy

This innovative treatment uses modified viruses and injects them into the cancer cells. Once an infection is created, the virus introduces new selected genes into the cells, which makes the cells easier to destroy. In some tests, the gene present in the virus assists in turning on the immune system to attack the cancer cells.

Virus therapies

Still in the early stages of testing, a specially created virus is put into the pleural space of the cancer cell. In the desired outcome, the virus would directly infect and then kill the cancer cells, or indirectly, the immune system would be encouraged to kill the cancer cells.

Targeted drugs

While chemotherapy has been used for some time but with limited success, there are newer chemotherapy drugs in tests that may do much more. These drugs are targeted to a specific type of cell or protein instead of standard chemotherapy that affects the whole body. This means there are usually fewer side effects.

Photodynamic therapy

While it sounds futuristic, there are a number of clinical trials in process that study the use of photodynamic therapy (PDT). Veins are injected with a light-activated drug. Once in the body, it spreads into cancer cells throughout the body. After a few days, a tube with a special red light on the tip is placed into the chest, usually after a surgery. The drug is activated by the light producing a chemical change that kills the cancer cells. Because all this happens only within the cancer cells, there may be fewer side effects.

Encouraging progress

The knowledge that studies continue in search of a mesothelioma cure should be an encouragement to anyone diagnosed with the disease or who have a experienced extended exposure to asbestos. Contact your doctor or this link to view current trials and, perhaps, find a new trial that interests you. There is hope, and we need to support those who are researching for ways to combat and kill mesothelioma before it continues its deadly toll.