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A New Treatment Doubles Mesothelioma Survival Rates

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A study at the University Hospital of Udine, Italy found that radical hemithoracic radiology, a new treatment doubles mesothelioma survival rates. The patients studied had cancers that were unable to be totally removed with surgical procedures. Mesothelioma patients generally live a year or, more rarely, up to two years. In this study of 108 patients, half were randomly selected to receive the new treatment and half the more palliative radiotherapy. Of those receiving the new, 58% were still living at two years. Of patients who received the more palliative radiotherapy, only 28% were still living at two years.

Mesothelioma and asbestos

The relationship between asbestos and mesothelioma is well known. The fibers from asbestos – smaller than a human hair – can embed in the layers of tissue surrounding the lungs. Not everyone exposed to asbestos contracts the disease, but it’s always a possibility. It’s an aggressive and fatal cancer that can take up to 50 years for a diagnosis. Current treatments are limited, so all new strides deserve a celebration.

Radical hemithoracic radiology a hopeful improvement for survival

Marco Trovo, MD, leader of the study and Chief of the Radiation Oncology Department at the University Hospital said, “There is an urgent need for more effective treatments for mesothelioma. Surgery can be given to these patients, but it is often impossible to remove all of the tumor. Patients with mesothelioma are sometimes given radiotherapy to help control their symptoms. However, radiotherapy has evolved dramatically in the last few years, so we wanted to see if it could now be used to prevent the cancer from spreading to nearby tissue, hopefully bringing improvements in survival.”

About 20% of the new radical treatment patients did develop radiation pneumonitis as a side effect. Professor Umberto Ricardi, President of ESTRO and head of the Department of Oncology at the University of Turin, Italy stated, “This is an extremely positive result that brings good news to patients with this rare and difficult-to-treat cancer. To ensure these patients benefit from this type of treatment, it’s important that they are referred to a specialist cancer centre with the right expertise and equipment to carefully plan and deliver the most effective radiotherapy treatment and manage any side effects that occur.”

New treatment doubles mesothelioma survival

Dr. Trovo said, “This research shows a clear survival benefit in using this type of radiotherapy for [patients with] mesothelioma whose tumors can only partially be removed by surgery. We believe that this should be considered the new standard of care for these patients.”

He believes that even longer survival rates could be made by using the new radiation technique followed by an immunotherapy technique that uses the patient’s immune system to target and fight the cancer cells. Creative scientific studies continue throughout the world with the goal of curing the deadly disease.

First New Mesothelioma Therapy Approved by FDA in Over 15 Years

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The first new mesothelioma therapy approved by the FDA is based on a trial. In this single-arm STELLAR trial, the median overall survival rate was 18.2 months with patients with unresectable, locally advanced or metastatic malignant pleural mesothelioma who received TTF plus chemotherapy. This combination of treatments comprises the NovoTTF-100L System along with pemetrexed and platinum-based chemotherapy for front-line treatment.

History of new mesothelioma therapy

Bill Doyle, executive chairman of Novocure, the developer of NovoTTF-100L stated, “Since 2000, we have been developing and commercializing Tumor Treating Fields (TTF) to extend survivals in some of the most aggressive forms of cancer. FDA approval of NovoTTF-100L provides patients with the first FDA-approved treatment for MPM in more than 15 years and, as our first FDA-approved torso cancer indication, marks a major milestone for Novocure. We are thankful for the patients, caregivers and health care providers who partnered with us to make this possible.”

What is malignant pleural mesothelioma (MPM)?

Strongly linked to asbestos exposure, MPM is a rare malignancy. Approximately 3,000 people are diagnosed with MPM each year in the US. This new therapy is welcome news as there was only one FDA-approved therapy prior to the NovoTTF-100L approval. That treatment consisted of pemetrexed plus cisplatin.

In addition to extending life, this new mesothelioma therapy approved by the FDA, is noninvasive, delivering TTF directly to the region of the tumor. No increase in serious systemic wide effects were noted with this new therapy.

Results showed patient overall survival at:
• 21.2 months for epithelioid malignant pleural mesothelioma (53 patients)
• 12.1 month for non-epithelioid malignant pleural mesothelioma (21 patients)
• 62% of those in the STELLAR study were alive at one year.
• Disease control when at least one CT scan was given as a follow-up was 97% (72 patients).

Mary Hesdorffer, NP, executive director of the Mesothelioma Applied Research Foundation, said “MPM is a devastating disease, with only 10 to 20 percent of patients being candidates for surgery to remove the tumor. Typically, mesothelioma patients who cannot have surgery receive palliative care to mitigate their symptoms. NovoTTF-100L provides unresectable MPM patients with a treatment option that may improve survival. We are encouraged by the FDA approval and hope it is just the beginning of innovation in the treatment of this aggressive disease.”

Two Decades After Ban, Asbestos Still Kills 5,000 Britons Each Year

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Not surprisingly, two decades after the ban, asbestos still kills 5,000 Britons each year. That’s because symptoms of disease often don’t show up until 20 to 40 years – or more – after exposure. This long exposure time is one of the reasons it is often not recognized as an imminent danger, yet the fibers inhaled many years in the past are poised to show up as lung cancer, asbestosis, or the deadly mesothelioma after the initial exposure is just a memory.

Asbestos still kills 5,000 Britons each year

The long exposure time is only one reason it is still killing after all these years. Though the mineral was outlawed 20 years ago in Britain, asbestos still exists in government, commercial, and residential buildings built before 1999. While not a threat when undisturbed, these buildings often are at an age when renovation, or even demolition, is required. If this work is not done by an authorized abatement company, the possibility of exposure from the dust created is high. To cut corners, renovators and do-it-yourself handymen often skip this critical step and the countdown to possible diseases in the distant future starts again.

The report from the Institution of Occupational Safety and Health (IOSH) verified that people today are still being exposed – often because of non-compliance with regulations. In the past year, over 130 British companies or individuals were ordered to stop work because of rule-breaking.

As Bev Bessinger, IOSH chief executive said, “It is unacceptable that 20 years on from asbestos being banned in Britain, organisations are still potentially putting at risk the lives of employees, their families, and other members of the public. Thousands die in Britain every year from cancers like mesothelioma, while many more are diagnosed with it. All this is preventable through good occupational safety and health. It is time for organisations to wake up and realise how dangerous asbestos is. There are no excuses.”

Dr. Nick Hopkinson, medical director at the British Lung Foundation, reinforced this message by confirming, “Currently the only treatments available are aimed at slowing the progression of the disease and improving quality of life. This devastating disease is preventable, and the dangers of asbestos are well known. It’s vital companies are vigilant and take the proper precautions to protect people from the life-threatening dangers of asbestos, and take urgent action if asbestos has been found.”

Asbestos still kills 15,000 Americans each year

This number of deaths is not acceptable. The United States has not taken the necessary steps to ban asbestos, even though it has been banned in 55 countries. Though some uses are no longer allowed in the US, others are – especially in commercial applications. We know homes and other buildings constructed before the 1980s have a high likelihood of asbestos in areas such as drywall, insulation, siding, roofing, tile mastic, and insulation around pipes. When will the US stop new uses of this deadly mineral?

Brakes on the Toxic Substances Control Act

This act showed promise to finally ban, or strictly control, asbestos as it was identified as one of the ten high risk chemicals set for EPA evaluation. Unfortunately, the ground rules for the EPA’s evaluation under the Trump administration has softened the likelihood of a ban and shockingly, may perhaps even allow new uses of the fiber.

A legacy of death for the future

Like those in the U.K. who work on demolition or renovation of pre-1980 era buildings, workers and their families can be exposed to asbestos if not careful to have suspicious areas checked by an abatement professional. Click here to see a comprehensive FAQ checklist of asbestos products, reporting information, and testing guidelines. Since there is no outright ban, new asbestos-containing materials can still be imported into the US. As seen in the British report, once a ban is in place, people contracting asbestos-related diseases continue for decades into the future. Until importation and new uses are stopped completely, there is no end in sight for the victims of asbestos.

Ben DuBose Named 2019 President of the Dallas Trial Lawyers Association

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February 27, 2019
Dallas, Texas

Trial lawyer, Ben DuBose, took office in January as the 2019 president of the Dallas Trial Lawyers Association.

Founded in 1963, the Dallas Trial Lawyers Association is a volunteer body of Dallas area trial attorneys. DTLA’s mission: empowering and supporting Dallas trial lawyers in achieving justice for those who have been harmed. For more information about DTLA, visit www.dallastriallaywersassociation.org

“The Dallas Trial Lawyers Association is the only Dallas area bar association devoted exclusively to supporting Dallas trial lawyers. I’ve been a DTLA member my entire career, having served on the Board of Directors and as a chair of the diversity committee in more recent years,” says DuBose. “DTLA helps lawyers who help people. Critical to that is supporting and protecting one of our fundamental rights as Americans – the right to trial by jury.”

DTLA members enjoy up to 7 hours annually of continuing legal education (CLE) at monthly luncheons. This year, DTLA also offers 3 hours of free CLE breakfasts sponsored by the association’s mentorship committee. Several social events are also held throughout the year for association members. During 2019, DTLA will also continue to build on recent joint projects with other local bar organizations including the Dallas Bar Association, the Dallas Hispanic Bar Association, J.L. Turner Association and the Dallas Women Lawyers Association.

Mr. DuBose has 23 years of experience representing asbestos, personal injury and wrongful death victims as well as individuals in employment matters. DuBose Law Firm, PLLC enters its second decade with offices in Dallas at the historic Adelfa B. Callejo Building and New Orleans.

Media Contact:
Jane Zavala
jzavala@duboselawfirm.com
(214)389-8199

Sponsored by Attorney Ben K. DuBose licensed in TX, OK, & PA

DuBose Law Firm, PLLC
Principal office:
4310 N. Central Expressway
Dallas, TX 75206
(214)389-8199

Asbestos Stopped the Clock

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Asbestos in LSU clock tower
LSU Clock Tower

After almost a hundred years of service, the Louisiana State University (LSU) Memorial Tower in Baton Rouge was ready for restoration, but asbestos stopped the clock tower project when the potentially deadly mineral was found in the interior.

History

The tower was built in the early 1920s in memory of 1,447 Louisiana soldiers who died in World War I. The interior of the tower houses a military museum.

The Memorial Tower clock holds a special place in the heart of students and the community for its chimes. The bells ring every quarter hour until 10 pm and at noon they ring the tune of the university’s alma mater song. On Valentine’s Day, tradition states that receiving a kiss under the tower at the ringing of the chimes at midnight – the only night they ring past 10 pm – confirms a student is now an “official” LSU student.

The 175’ tall building was designed in the Italian Renaissance style and is a landmark in the city.

From its history, it is evident the tower is an important part of Louisiana’s past – from its construction in 1923, to today, and into the future. The restoration will ensure the building and its traditions carry on for future generations of students.

The restoration

Finding asbestos was not completely unexpected, as many buildings in the United States were built using the mineral from the 1920s until the late 1970s. Until renovations began, the asbestos was undisturbed and therefore not a danger. But once substances containing asbestos are handled, fibers can become airborne and inhaled by workers or others who are in the affected area.

When found in the tower, work on the interior was stopped and tests are currently underway. Most other buildings on the LSU campus were also constructed during this time period, meaning that as they are restored, they may also need testing and possibly abatement.

Because the asbestos was discovered at the beginning of the restoration, the university states there is no threat to students or faculty members. As a precaution, remodeling or renovations performed on any commercial buildings, schools, or residences during the time period asbestos was commonly used in construction, may require testing on possible asbestos-laden products before initiating a project.

Exposure to asbestos is a known cause of cancers, such as lung cancer and mesothelioma. At this time, mesothelioma remains a fatal disease. Mesothelioma can go undetected for decades – even 50 years – which makes it a silent killer. Early detection is critical.

Asbestos stopped the clock, but it will chime again

Exterior renovations continue and the entire $6.8 million project should be completed by the 2020 Fall semester. Baton Rouge, especially LSU students and alumni, look forward to enjoying their celebrated clock tower once again.

Photo by: Kkmurray – Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=2666826