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Studies Continue in Search of a Mesothelioma Cure

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Mesothelioma is a disease primarily caused by asbestos exposure and is usually fatal within a short period of time, however studies continue in search of a mesothelioma cure. This is not a simple task, as researchers are still not sure of the reason asbestos fibers encourage cancer in some individuals. With the long latency period between exposure and diagnosis, people will be fighting this disease for many decades to come. That means that new treatments to defeat the disease are urgently needed.

In the past, and currently, treatments often consisted of chemotherapy, radiation therapy, or surgery. These have extended the lives of many patients and they still do. However, as noted by the American Cancer Society, there are new studies and treatments that carry the promise that they may do more than extend life for a few months and actually bring about a cure.

What are the latest treatments?

While there are treatments currently in use, they are often limited in their effect and generally extend life a little longer rather than cure the disease. New ideas and studies take place all the time. Some of the newest treatments still under testing are listed below.

Immunotherapy

Clinical trials are underway using a patient’s own immune cells to attack their cancer. These cells are removed from the blood, taken to the lab where they are manipulated to react to tumor cells. They are then put back into the patient’s body through a blood transfusion. The presumption is these transformed immune cells will encourage the patient’s immune system to kill the cancer cells.

One other immunotherapy in trials uses tremelimumab, a drug that encourages the immune system to attack full force as it targets specific immune cells.

Gene therapy

This innovative treatment uses modified viruses and injects them into the cancer cells. Once an infection is created, the virus introduces new selected genes into the cells, which makes the cells easier to destroy. In some tests, the gene present in the virus assists in turning on the immune system to attack the cancer cells.

Virus therapies

Still in the early stages of testing, a specially created virus is put into the pleural space of the cancer cell. In the desired outcome, the virus would directly infect and then kill the cancer cells, or indirectly, the immune system would be encouraged to kill the cancer cells.

Targeted drugs

While chemotherapy has been used for some time but with limited success, there are newer chemotherapy drugs in tests that may do much more. These drugs are targeted to a specific type of cell or protein instead of standard chemotherapy that affects the whole body. This means there are usually fewer side effects.

Photodynamic therapy

While it sounds futuristic, there are a number of clinical trials in process that study the use of photodynamic therapy (PDT). Veins are injected with a light-activated drug. Once in the body, it spreads into cancer cells throughout the body. After a few days, a tube with a special red light on the tip is placed into the chest, usually after a surgery. The drug is activated by the light producing a chemical change that kills the cancer cells. Because all this happens only within the cancer cells, there may be fewer side effects.

Encouraging progress

The knowledge that studies continue in search of a mesothelioma cure should be an encouragement to anyone diagnosed with the disease or who have a experienced extended exposure to asbestos. Contact your doctor or this link to view current trials and, perhaps, find a new trial that interests you. There is hope, and we need to support those who are researching for ways to combat and kill mesothelioma before it continues its deadly toll.

Mesothelioma Awareness Day and ADAO, the Group that Started it All

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The Asbestos Disease Awareness Organization, ADAO, was the group that started it all. It began in 2004 when two people, Doug Larkin and Linda Reinstein, who had loved ones suffering from mesothelioma saw a need and worked to find a way to stop this deadly disease. They found it through the ADAO as they began spreading the message about asbestos and mesothelioma.

Today is Mesothelioma Awareness Day, started by ADAO, and a perfect time to look at this amazing organization that makes fighting for past, current, and future victims of asbestos its goal.

The journey

Caring for, and watching their family members die, put the founders in contact with others going through the same painful journey – a journey that could be prevented for the generations to come if the mineral at the heart of it all could be banned. Fourteen years later, it is still not banned in the United States, but is in many parts of the world.

This group started slowly but gathered momentum as other victims and their family members learned of its existence. Today, thanks to people from all walks of life: patients, caregivers, and a host of donors and volunteers, the ADAO boasts a network of over 50,000 people who share in this quest to eradicate mesothelioma and other asbestos-related diseases from the world.

More than a ban

While the ADAO does strive for a ban, their mission goes beyond that with three initiatives: education, advocacy, and community.

Education

The ADAO has gathered a built an extensive library that is shared throughout the globe, along with a website brimming with information about asbestos and what you can do. There are speakers at conferences and events around the world presenting opportunities to interact and share information with others on similar missions. Each year, the ADAO hosts its own conference, the International Asbestos Awareness Conference where the latest information on the status of prevention and treatments is shared. In 2019, the conference will be in Washington, D.C. on April 5-7.

Advocacy

Since 2004, the ADAO has presented 13 staff briefings for the U.S. Senate and House of Representatives. They’ve created and sponsored a bill, the Alan Reinstein Ban Asbestos Now Act, that is supported by both the House and the Senate. This bill would require the Environmental Protection Agency (EPA) to finally – and permanently – remove the possibility of all human or environmental asbestos exposure.

Community

Caring for someone suffering from mesothelioma is an isolating experience. Linda Reinstein experienced that as she cared for her husband and knew it was an important part of the ADAO mission to support those with the disease and those caring for them. There are groups throughout social media to provide contacts and support without leaving home, there are campaigns, like “Share Your Story” and “6 Word Quotes” that educate about the dangers of asbestos and unite those living with the aftermath of exposure.

The fight continues

Until asbestos is banned throughout the world and there is no one suffering any longer from this disease, the ADAO will continue to fight to educate, support, and bring the issues of exposure to those in government who can make a difference.

You can sign a petition to the EPA for a final ban on asbestos, follow the ADAO on Facebook and Twitter, and get their eNewsletter – all ways to stay informed.

On September 26th We Remember Asbestos Victims and Push Forward for a Ban

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The Asbestos Disease Awareness Organization (ADAO) takes asbestos exposure seriously as they have heard the stories of thousands who have died, and so each year on September 26th they remember asbestos victims and push forward for a ban on this deadly mineral.

While many countries around the world have banned the use and import of asbestos, it is still legal in the United States. It is proven to be a cancer-causing substance for those exposed as there is no safe level of exposure to asbestos.

Mesothelioma Awareness Day

This year the ADAO has moved from a Mesothelioma Awareness Day on September 26th to proclaiming September a Mesothelioma Awareness Month to increase the reach to people that can be educated to the threat of asbestos use and the need for caution when working with any material that may contain asbestos.

How can we remember asbestos victims and push forward for a ban?

• Right now you can sign a petition to ban asbestos. By clicking this link, you’ll be directed to a page where you can sign. The more legislators who see the interest of citizens for a ban, the more they can push the Environmental Protection Agency (EPA) to increase the current rules, recognize the dangers, and get to the point of an outright ban.

• Join the chat on Twitter September 26th, from 12-1 PM ET. Go to #ENDMeso – for that hour, you’ll find questions about asbestos awareness as well as comments from people personally affected by asbestos exposure and mesothelioma, a deadly disease directly connected to exposure. The purpose is to create a global conversation between experts, victims, advocates, and anyone concerned about the dangers and the long delay in stopping the use of asbestos in the US.

• Light a candle on September 26th for the Mesothelioma Warriors lost to the disease and those who continue to fight for their lives.

• Participate in the 9th Annual Miles for Meso 5K Race and 3K Walk/Fun-Run. Last year $30,000 was raised to help fund awareness and education efforts. The race in in Alton, Illinois, but is available to anyone through the ADAO’s Virtual Team where you can join in from the front of your computer.

The urgency of a ban

Mesothelioma is a disease that often takes decades to appear after exposure. It currently has no cure. Because of the long lag between exposure and diagnosis, people exposed today may not develop the disease until 2050! This cycle needs to stop now and asbestos must be banned to stop it.

In addition to the steps you can take outlined above, you can donate to the ADAO as a partner in the fight for a ban. You can directly contact the EPA and your legislators. You can be an advocate for the health of many by adding your voice to stop the import and use of asbestos now.

Flintkote in New Orleans: Fifty Years of Asbestos Exposure in Manufacturing

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The Flintkote Company established its product line in Massachusetts for over 30 years before opening a plant in New Orleans in the late 1930s. Thus began forty years of asbestos exposure in manufacturing roofing products and floor tiles in NOLA. 

By 1963, Flintkote had 147 plants, including 21 international. Though they produced gypsum, paper products, pipes, and other cement and asbestos products, their focus was on construction materials throughout the 1970s. But in 1987, Flintkote sold its construction, stone, and cement products units as they turned their attention to their enormous asbestos liabilities.

Flintkote today is known for its asbestos-related lawsuits. The company filed for Chapter 11 bankruptcy in 2004. At that time, they had paid $630 million for over 350,000 asbestos claims with over 155,000 cases yet to be tried at the time of bankruptcy. They remain liable for damages created by their use of asbestos. 

Asbestos exposure in manufacturing

The New Orleans plant was located at Poland Avenue and N. Galvez Street along a waterway that flowed directly into the Mississippi River. Workers handled raw asbestos here while adding it to roofing products and floor tiles. This continued at the New Orleans plant until the late 1970s. 

Results of asbestos exposure

By handling the asbestos with no protection, the microscopic fibers were allowed to permeate the air and, subsequently, enter the lungs through inhalation. These fibers can stay in the lungs for years – or decades – until possibly leading to lung cancer, asbestosis, or the fatal mesothelioma.  

Even today, there are workers fighting for justice after exposure at this plant. If you, or a loved one, believe you were exposed to asbestos, it is critical to see a doctor for regular medical exams. 

Asbestos Job Sites Louisiana

Will Elephants Help Scientists Find a Way to Combat Human Cancers?

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New cells going awry as they replace older cells in the body can often lead to cancer, but a study in the Cell Reports journal describes a way that elephants may lead scientists to new ways to combat human cancers.

Bigger may be better

Since cells are a critical component of acquiring cancer, it is reasonable to think that a large mammal, such as an elephant, would develop more cancers than a smaller mammal, such as a human, since it would clearly have hundreds of times more cells in its large body. However, elephants rarely get cancer in any form.

A paper published by Joshua Schiffman, a pediatric oncologist at the University of Utah, and his team, pointed out an interesting finding showing organism size and cancer rates are the reverse of what rational thought would suppose. In our bodies is a tumor-suppressing gene – P53. Whereas humans have one copy of this important gene; elephants have 20.

The purpose of P53

P53 acts as a genetic triage manager, recognizing abnormal DNA and determining whether to repair or destroy the cell. This is where elephants excel with their overload of P53. For the most part, damaged cells in elephants are killed, not repaired, while other mammals – including humans – tend to try to repair first. Since these damaged cells are killed immediately in elephants, they don’t have time to become cancerous.

Vincent Lynch, who led the study team and is an evolutionary biologist at the University of Chicago, stated, “Elephants are weird. Their cells just die if you give them DNA damage.” He wanted to know why. This quest lead to finding the answer in LIF genes.

What are LIF genes?

He found this strange phenomenon by looking for what genes might be genetically different between an elephant and other small-bodied mammals. Primarily they were looking for genes with extra copies. That’s when he found that one gene, Leukemia Inhibitory Factor, or LIF – known for enhancing fertility – also killed aberrant cells. Almost every mammal, including humans have one copy of LIF, but elephants, manatees, and the hyrax, have many. Elephants have anywhere from 7 to 11 copies. LIF6 is the only gene that appears to act as the executioner when P53 orders a cell killed and only elephants have that specific gene.

Lynch and his team confirmed their suspicions by damaging DNA from African elephant cells in the lab. This pulled the trigger for P53 to give orders to the LIF6 gene, which then killed the damaged cells. But, when LIF6 was made non-functioning, the P53 had nowhere to turn and the elephant sensitivity to cell damage no longer worked, leaving the damaged cells free to roam and multiply.

Ways to combat human cancers are just beginning

P53 and LIF6 functions in elephants are remarkable finds, but there is more to study. In fact, one ongoing study focuses on a set of genes that works to repair elephant DNA instead of killing the cells.

Researchers hope that these in-depth studies of cancer defenses in elephants will be the start of finding additional treatments for cancer in humans.